The short answer
Protein helps preserve muscle while you lose weight. The adult RDA is 0.8 grams per kilogram of body weight a day, and the 2025–2030 Dietary Guidelines set a higher goal of 1.2–1.6 g/kg. With a small appetite, eat protein first and choose compact foods like Greek yogurt, eggs, cottage cheese and beans. Your doctor or a registered dietitian should set your personal target.
When a few bites fill you up, the first bites count. Protein helps protect your muscle while you lose weight, and a short list of foods packs plenty of it into a small serving. Use the numbers below as background, and get your personal target from your doctor or a registered dietitian.
Why does protein matter while you're losing weight?
When you lose weight, you lose some muscle along with fat. A 2025 joint advisory on nutrition during GLP-1 therapy, from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association and The Obesity Society, says rapid weight reduction from GLP-1 use frequently leads to loss of both fat and muscle mass. In the STEP 1 trial of semaglutide, the advisory reports, 62% of the weight participants lost was fat mass and 38% was lean body mass. Because muscle makes up about half of lean mass, the authors estimate that roughly 20% of the total weight lost was muscle.
A 2017 review in Advances in Nutrition describes a similar pattern in weight loss generally: in people with overweight or obesity, fat-free mass contributes about 20% to 30% of the total weight lost. The review notes that reduced muscle strength and power are key predictors of serious adverse outcomes in older adults. The joint advisory adds that eating less protein because of a smaller appetite may contribute to muscle loss and a higher risk of sarcopenia, meaning low muscle mass and impaired muscle function.
Protein is part of the answer. The review concludes that high protein intake helps preserve lean body and muscle mass during weight loss, and its authors recommend adequate, but not excessive, protein. MedlinePlus, from the National Library of Medicine, explains that you need protein to help your body repair cells and make new ones.
How much protein do you need each day?
Official guidance gives you background numbers, and they don't all match:
| Guideline | Amount | Where it comes from |
|---|---|---|
| Recommended Dietary Allowance (RDA), adults | 0.8 g per kilogram of body weight per day (about 0.36 g per pound) | Cited in the 2025 joint advisory and the 2017 Advances in Nutrition review |
| RDA in grams per day, adults 19 and older | 46 g for women, 56 g for men | Dietary Guidelines for Americans, 2020–2025, Appendix 1 |
| Protein goal in the current Dietary Guidelines | 1.2–1.6 g per kilogram per day, adjusted to your calorie needs | Dietary Guidelines for Americans, 2025–2030 |
| Range proposed during active weight loss | 1.2–1.6 g per kilogram per day | 2025 joint advisory |
| Share of daily calories | 10% to 35% | MedlinePlus |
The RDA is the baseline for adults. The 2025–2030 Dietary Guidelines for Americans, from the U.S. Department of Agriculture and the U.S. Department of Health and Human Services, set a higher protein goal. The joint advisory says higher targets such as 1.2–1.6 g/kg a day have also been proposed during active weight reduction.
None of these is your personal number. Your target depends on your body, your health and your treatment. Ask your doctor or a registered dietitian to set it with you.
Why is protein harder to eat when you're not hungry?
Cleveland Clinic explains that the satiety effect of GLP-1 agonists, the feeling of fullness after eating, reduces food intake, appetite and hunger. MedlinePlus notes that semaglutide slows the emptying of the stomach. A portion that once felt small may now feel like plenty.
The joint advisory says that for people on GLP-1s, adequate dietary protein may be difficult to achieve due to reduced appetite or taste aversions. If meat suddenly sounds unappealing, you're not doing anything wrong. Other protein foods can fill the gap.
Which small foods pack the most protein?
The advisory suggests lower-volume, nutrient-dense protein foods such as fish, eggs, Greek yogurt, cottage cheese, and nuts and seeds, including their spreads. The amounts below come from USDA FoodData Central. Half-cup weights are half the USDA cup weight. Brands vary, so check the Nutrition Facts label on what you buy.
| Food (USDA entry) | Serving | Protein |
|---|---|---|
| Egg, whole | 1 large egg (50 g) | 6.3 g |
| Greek yogurt, plain, lowfat | 1 container, 7 oz (200 g) | 19.9 g |
| Cottage cheese, lowfat, 2% milkfat | 4 oz (113 g), about 1/2 cup | 11.8 g |
| Mozzarella, low moisture, part-skim | 1 oz (28 g) | 6.7 g |
| Milk, reduced fat (2%) | 1 cup (244 g) | 8.1 g |
| Tuna, light, canned in water, drained | 3 oz (85 g) | 21.7 g |
| Chicken breast, roasted, meat only | 1/2 breast, bone and skin removed (86 g) | 26.7 g |
| Black beans, cooked | 1/2 cup (86 g) | 7.6 g |
| Edamame, frozen, prepared | 1/2 cup (about 78 g) | 9.2 g |
In this list, chicken, tuna and a container of Greek yogurt deliver the most protein per serving. Eggs and cheese come in ready-made small portions. Beans and edamame work if you eat little or no meat.
Small servings add up over a day. Using the USDA numbers above, these five small portions come to 65.2 g of protein:
- 1 large egg at breakfast: 6.3 g
- A 7-oz container of plain Greek yogurt mid-morning: 19.9 g
- 3 oz of canned light tuna at lunch: 21.7 g
- A cup of 2% milk in the afternoon: 8.1 g
- 1/2 cup of edamame with dinner: 9.2 g
Treat this list as an example of the math. It is not a meal plan, and your own number should come from your doctor or dietitian.
What habits make it easier to get enough?
- Eat protein first. The joint advisory says protein-rich foods can be eaten first in a meal to increase the likelihood of getting enough. Start with the egg, the chicken or the beans, then move to the rest if you still have room.
- Eat small and often. The advisory says small, frequent meals may work when hunger and interest in food are low. A few bites of protein every few hours add up over a day.
- Drink some of it. The advisory notes that some people meet protein targets with high-protein shakes, bars and other fortified products, and it mentions smoothies made with fruits, vegetables, unsweetened milks or yogurt. A cup of 2% milk has 8.1 g of protein, according to USDA. If you buy a ready-made shake, compare protein and added sugar per serving on the label, and ask your doctor or dietitian whether one fits your plan.
- Add protein to what you already eat. Stir cottage cheese into scrambled eggs, add beans to soup, or top a salad with tuna.
- Keep it ready. Hard-boil a few eggs, portion yogurt into small containers, and keep canned tuna and frozen edamame on hand for low-effort days.
- Try a smaller plate. If a big plate of food feels like too much, a smaller one may be easier to face. Next Size Club's accessories shop carries portion plates.
Fluids need attention too. See the guide to staying hydrated on a GLP-1. If December parties are coming up, the guide to holiday parties on a GLP-1 covers eating small at a buffet.
When should you talk to your doctor or a dietitian?
Bring protein up with your care team when:
- You want a daily protein target that fits your body and treatment.
- You struggle to eat enough of anything most days.
- Protein foods make nausea, fullness or constipation worse.
- You have a health condition that affects what you can eat.
- You're considering protein powders or other supplements.
The joint advisory says a registered dietitian nutritionist can help determine a dietary pattern that meets your nutrition goals, and that pairing GLP-1 use with dietitian counseling should support staying on the medication. Ask your prescriber for a referral. Before the visit, write down what you eat for three days, including portion sizes, so the dietitian has something concrete to work from.
Members of Next Size Club get a capsule of about 6 everyday basics in their current size, and a new one each time their size changes, plus a monthly comfort kit with hydration, snacks and small comfort items. See how membership works.
This guide is general information, not medical advice. Next Size Club does not sell, prescribe or recommend medication. For anything about your treatment, talk to your prescriber.
Questions people ask
Can you get enough protein without eating meat?
MedlinePlus says you do not need to eat animal products to get all the protein you need, and it lists soy, beans, legumes and nut butters as plant sources. In USDA data, half a cup of prepared edamame has 9.2 g of protein and half a cup of cooked black beans has 7.6 g. A registered dietitian can help you plan a plant-based day that reaches your target.
Are protein shakes a good idea when you can't eat much?
The 2025 joint advisory notes that some people meet their protein targets with high-protein shakes, bars and other fortified products. Labels differ from product to product, so compare protein and added sugar per serving. Ask your doctor or a registered dietitian whether a shake fits your plan, especially if you have a health condition.
Is more protein always better?
Not necessarily. The 2017 Advances in Nutrition review found that high protein intake helps preserve lean mass during weight loss, but it does not improve muscle strength and could have adverse effects on metabolic function. Its authors recommend adequate, not excessive, protein. Your doctor or dietitian can tell you where that line sits for you.
Should my protein target be based on my current weight?
That is an open question. The 2025 joint advisory says it is unclear whether per-kilogram targets should use actual, adjusted or fat-free body weight, and that using actual weight can overestimate protein needs. A registered dietitian can help you choose the right basis for your number.
What if protein foods make me feel uncomfortable?
Tell your care team. The 2025 joint advisory notes that foods high in protein or fat can further slow gastric emptying, and for people dealing with constipation it says these foods may need temporary limitation. Your doctor or dietitian can help you adjust your plan.
Sources
- Obesity (2025), Mozaffarian D, et al. — Nutritional priorities to support GLP-1 therapy for obesity: A joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society
- Advances in Nutrition (2017), Cava E, Yeat NC, Mittendorfer B — Preserving Healthy Muscle during Weight Loss
- U.S. Department of Agriculture and U.S. Department of Health and Human Services — Dietary Guidelines for Americans, 2025–2030
- U.S. Department of Agriculture and U.S. Department of Health and Human Services — Dietary Guidelines for Americans, 2020–2025 (Appendix 1, Table A1-2)
- MedlinePlus (National Library of Medicine) — Protein in diet
- MedlinePlus (National Library of Medicine) — Semaglutide Injection
- Cleveland Clinic — GLP-1 Agonists: What They Are, How They Work & Side Effects
- USDA FoodData Central — Egg, whole, raw, fresh (FDC ID 171287)
- USDA FoodData Central — Yogurt, Greek, plain, lowfat (FDC ID 170903)
- USDA FoodData Central — Cheese, cottage, lowfat, 2% milkfat (FDC ID 172182)
- USDA FoodData Central — Cheese, mozzarella, low moisture, part-skim (FDC ID 171244)
- USDA FoodData Central — Milk, reduced fat, fluid, 2% milkfat, with added vitamin A and vitamin D (FDC ID 171267)
- USDA FoodData Central — Fish, tuna, light, canned in water, without salt, drained solids (FDC ID 171986)
- USDA FoodData Central — Chicken, broilers or fryers, breast, meat only, cooked, roasted (FDC ID 171477)
- USDA FoodData Central — Beans, black, mature seeds, cooked, boiled, without salt (FDC ID 173735)
- USDA FoodData Central — Edamame, frozen, prepared (FDC ID 168411)


